The blocking action of pronethalol on the contraction of isolated spleen strips produced by adrenaline, acetylcholine or isoproterenol.

木崎 静子 ・安孫子 保 It has been reported that spleen strips contract with an addition of adrenaline (1 3), noradrenaline (3), acetylcholine (1-3), histamine (1-2) or 5-hydroxytryptamine (2) to the bath medium. The adrenaline-induced contraction of the spleen strips can be block ed by alpha-adrenergic blocking agents (1-4). According to Bickerton (4), isoproterenol, which stimulates beta-adrenergic receptors, also contracts the spleen strips and the iso